MANCHESTER, England (AP):The final round of international fixtures in 2016 did no favours for managers of some of the English Premier League’s title hopefuls.Jose Mourinho and Arsene Wenger, in particular, will vouch for that ahead of the renewal of their often-heated coaching rivalry.When Mourinho’s Manchester United and Wenger’s Arsenal meet at Old Trafford tomorrow for the standout game in the 12th round of matches, there could be some major names missing because of injuries sustained on international duty.United captain Wayne Rooney has caused a furore by being photographed, looking bleary-eyed, alongside some guests at a wedding party taking place at the England team hotel last Saturday. But by then, he’d picked up a knee injury during England’s 3-0 win over Scotland the night before, causing him to miss Tuesday’s match against Spain, and Rooney is now doubtful for the Arsenal game.SERIOUS DOUBTSIt was the last thing Mourinho would have wanted, considering he is already without suspended striker Zlatan Ibrahimovic and centre backs Eric Bailly and Chris Smalling, as well as having serious doubts over the fitness of midfielder Marouane Fellaini and full backs Luke Shaw and Antonio Valencia.Wenger, meanwhile, will ask Alexis Sanchez for an honest assessment of his fitness after Arsenal’s star forward sustained a hamstring injury while away with Chile. Sanchez missed a draw against Colombia, but returned for the 3-1 win over Uruguay on Tuesday, although his right leg was heavily strapped for the match.Sanchez isn’t due to return to Arsenal’s training base until today and the match against United is a lunchtime kick-off.”What I will consider is the risk of injury, because he played while recovering from a hamstring injury,” Wenger said yesterday. “I’ll consider the way he feels as well. On that front, you depend on the honesty of the player, how they feel and how they recover.”Wenger will be careful about overloading Sanchez, who has scored eight goals for Arsenal this season from his new position as converted striker. This time last year, Sanchez picked up a hamstring injury following a gruelling run of back-to-back games for club and country and ended up missing the next two months, which proved to be a huge blow to Arsenal’s title hopes.KEY PLAYER INJURIESLiverpool and Chelsea, the Premier League’s top two, could also be counting the cost of the recent international games after injuries to key players.Adam Lallana, one of Liverpool’s quartet of sprightly forwards that has been in devastating form this season, hobbled off during England’s game against Spain and is a doubt for the leaders’ trip to Southampton.As for second-place Chelsea, Diego Costa was ruled out of both of Spain’s games during the break because of groin injuryand Eden Hazard limped off during Belgium’s 8-1 win over Estonia with an apparent calf injury. It isn’t yet clear if either Costa or Hazard the scorers of 15 league goals between them will be fit for Chelsea’s match at Middlesbrough.Palace have conceded 10 goals in their last three games and have not kept a clean sheet in the league all season. In terms of points per game (0.73) in 2016, Alan Pardew’s side is the worst-performing team across England’s four leagues this calendar year.Probably, then, the last team they would want to see arriving at Selhurst Park tomorrow is Pep Guardiola’s free-scoring Man City side. Star striker Sergio Aguero will be raring to go for City, having failed to start for Argentina in either of their World Cup qualifying games over the international break.