Linkedin Facebook Garrett Podellhttps://www.tcu360.com/author/garrett-podell/ ReddIt Garrett Podell TCU guard Desmond Bane drives to the hoop in the Horned Frogs’ season opener against Cal-State Bakersfield. Photo by Cristian ArguetaSoto. ReddIt Boschini talks: construction, parking, tuition, enrollment, DEI, a student trustee Garrett is a Journalism and Sports Broadcasting double major. He is the Managing Editor for TCU360, and his passions are God, family, friends, sports, and great food. Garrett Podellhttps://www.tcu360.com/author/garrett-podell/ Twitter Listen: The Podell and Pickell Show with L.J. Collier printTCU guard Desmond Bane drives to the hoop in the Horned Frogs’ season opener against Cal-State Bakersfield. Photo by Cristian ArguetaSoto.TCU’s 2018-19 campaign started off slowly, but a strong second half from junior Desmond Bane, who scored 13 of his 14 points in the final 20 minutes, led the team to a 66-61 victory. He also earned a double-double, the first of his career with a team-best 10 rebounds.“I just stuck with it, there was times when other guys were getting open looks in the first half and it was falling my way in the second half,” said Bane. “My teammates kept trusting me, [Alex Robinson] kept telling me it’s going to come it’s going to come, so just staying patient, playing the game.”The Horned Frogs introduced six new players into their rotation while missing the service of veterans Jaylen Fisher and Kouat Noi.The first 20 minutes were forgettable for TCU, shooting just 37 percent from the field while allowing CSU Bakersfield to connect on 52 percent of their looks. Guarding the three-point line better, a defensive area emphasized by Dixon in the offseason, wasn’t reflected in the first half as CSU Bakersfield hit nearly half of their shots from distance.TCU, showing some first-game jitters, shot a meager 22 percent, two of nine, from the three-point line in the first half as they trailed 37-28 going into halftime.Redshirt freshman guard R.J. Nembhard was a bright spot for the Horned Frogs in the first half, scoring five of his eight points in the first 20 minutes. He finished his night with an additional four rebounds and two assists.“RJ has been pretty solid for us defensively, that’s the thing we’ve seen, and he’s been pretty solid offensively, the shooting obviously a couple shots down the stretch there that didn’t go for him but we’re happy with RJ,” head coach Jamie Dixon said.Redshirt freshman guard RJ Nembhard throws down an alley-oop lob from Alex Robinson against CSU Bakersfield. Photo by Cristian ArguetaSoto.With 13:15 left to play, the Horned Frogs utilized a 10-2 run to cut their deficit to two, 46-44 with 11:06 to play.A layup from the top-rated junior college recruit, center Yuat Alok, in traffic on a pin-point pass from Robinson evened the score at 46 with 7:53 left to play. Alok finished with 11 points and six rebounds in his TCU debut.Trailing by a point, the Horned Frogs regained their first lead since the opening minutes on a three-point play from Bane.The contest continued to swing back and forth, and the game eventually became tied once again, 57-57 with 3:10 left to play.Bane would follow with a layup on the next possession to give the Horned Frogs a two-point lead that they wouldn’t relinquish, hanging on for the last 2:48 to win 66-61. Freshman guard Kendric Davis hit four critical free throws in the closing five minutes, including two in the final 27.4 seconds to help the Horned Frogs clinch their 12th straight home opener victory.“I felt he’d [Davis] make free throws at that time and maybe another ball handler would help too,” Dixon said.”That was part of it. … He’s going to be a good player.”Freshman point guard Kendric Davis leads TCU on the fast-break against CSU Bakersfield in the season opener. Photo by Cristian ArguetaSoto.A season ago, the Horned Frogs were known for their offense, averaging 82.1 points per game, but winning a sloppier, defensive slug-fest left the team encouraged about their ability to grow as the season progresses.“We held them to 36 percent, shooting,” Dixon said. “That’s a good team, that’s an old team, that’s a tough team, that’s a well-coached team, Bakersfield, and that’s a team you don’t want to play early, first game of the year with three returning college basketball players, but we did it, we got a win and we’re going to get better for it.”Up NextThe Horned Frogs return to action at 4 p.m. Sunday inside Schollmaier Arena against the Oral Roberts Golden Eagles. Noi’s knee injury is not thought to be serious, and there’s a chance he will make his season debut Sunday.<span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> + posts Twitter TCU rowing program strengthens after facing COVID-19 setbacks TCU baseball finds their biggest fan just by saying hello Boschini: ‘None of the talk matters because Jamie Dixon is staying’ Men’s basketball scores season-low in NIT semifinals loss to Texas Facebook Garrett Podellhttps://www.tcu360.com/author/garrett-podell/ Previous articleStudents address diversity and inclusion in ‘Dear TCU’ campaignNext articlePatterson’s next-man-up philosophy being tested down the stretch Garrett Podell RELATED ARTICLESMORE FROM AUTHOR Linkedin Another series win lands TCU Baseball in the top 5, earns Sikes conference award Garrett Podellhttps://www.tcu360.com/author/garrett-podell/
Raptors to the White House?”To put it politely, I think it’s a hard no.” – @DGreen_14 pic.twitter.com/do6vyQa7O7— Yahoo Sports Canada (@YahooCASports) June 22, 2019Canadian prime minister Justin Trudeau already has extended an invite to the Raptors to visit Parliament Hill in Ottawa, though the details are still being worked out. Trudeau, who was in Washington earlier this week, asked Trump about inviting the Raptors to the White House. “We thought about that. That’s an interesting question,” Trump said (per USA Today). “… That was a great job by a great team, so we’ll think about that. If they’d like to do it, we’ll think about that.”Green added: “I’m sure he’s going to take his invite back now. If we do decide, he’s going to be like, ‘Well, I didn’t invite them anyway.’ That’s fine.” “I just don’t think that we accept,” Green said. “And I try to respect everybody in every field that they do regardless of how crazy things are. But he makes it really hard. He makes it very, very tough to respect how he goes about things and does things.”To put it politely, I think it’s a hard no.” Related News Even if the Raptors were invited to visit President Donald Trump at the White house, Raptors’ Danny Green doesn’t think the team would accept the invitation. After helping Toronto win its first NBA title in franchise history, Green was pressed during an appearance on Yahoo Sports’ “Inside The Green Room” about whether he would make the trip to the White House if the Raptors were to be invited. Toronto mayor begs Raptors fans to leave Kawhi Leonard alone ahead of free agency There is precedent for a team from Canada celebrating in Washington, D.C. after taking home a title in their respective league. The Toronto Blue Jays won the World Series in 1992 and visited with President George H. W. Bush that December. The Blue Jays, however, repeated as champions one year later and did not travel to the United States capital.Raptors president Masai Ujiri hinted the team was unlikely to visit the White House during Trump’s presidency at a press conference in 2017. “When we win a championship, we’ll deal with that issue,” Ujiri said at the time. “I think we get to go to two White Houses, right? If we win a championship, hopefully one day, I think we’ll be fine with Trudeau.”
Basketball players of Igokea have won BiH basketball Cup, after beating BC ”Široki Wwin” with 86:81 in Laktaši.Branko Jorović was the most efficient player of Igokea with 25 scored points, and Hammonds with 23. The best player of Široki was Freemen with 23 points.In semi-finals Igokea defeated Čapljina 93:65, and Široki Wwin defeated Posušje with 105:50.
By John BurtonRED BANK — A particularly problematic stretch of roadway through the borough will be getting Monmouth County’s attention beginning in August.Front Street – from its western portion in the area of English Plaza to its east section near Riverview Medical Center, across from Washington Street – is scheduled to have some rehabilitation and renovation construction work intended to make that corridor safer for pedestrian and vehicular traffic, according to William Heine, a Monmouth County spokesman.The project is scheduled to begin Monday, Aug. 6, and will take about four months to complete. It had been slated to start earlier but was delayed by gas utility work in the area, Heine said.The work has been budgeted at $634,000 and will be paid for, in part, by federal dollars, administered by the New Jersey Transportation Planning Authority, and county funds, according to Heine.The intent of the project is to standardize the width and “improve the geometry in the corridor to provide well-defined lanes in each direction,” Heine said. The work will include creating turning lanes and some additional on-street parking.Contractors are expected to install friction- and skid-resistant material along portions of the roadway and resurface the road. The area, especially near the medical center, will be constructed to comply with the American with Disabilities Act by building handicap accessible ramps. Flashing pedestrian crossing signs and slightly elevated crosswalks also will be installed, along with colored striping that should help make pedestrians more noticeable to oncoming traffic, Heine said.The project calls for curb extensions, which will narrow the roadway in spots to force vehicles to merge into single lanes, and the installation of “bulb-outs,” which Heine said are curb extensions at intersections, that will give those waiting to cross the street greater visibility.The traffic light at East Front Street and Globe Court will be upgraded to enhance traffic flow, he said.The section of the Front Street corridor, intersecting the downtown business area, has been the site for a number of collisions involving pedestrians and vehicles and with vehicles and vehicles. In April 2006 there was a fatal accident on East Front Street when a vehicle struck a Riverview employee as he crossed the road.Earlier this month, a 24-year-old Ocean resident was hit by a vehicle and suffered minor injuries as she crossed at the corner of West Front and Broad streets. The vehicle was attempting to make a left from Broad to West Front when it struck her.The driver, a 31-year-old Highlands man, was issued a summons for failing to yield to a pedestrian, according to Capt. Darren McConnell, a police spokesman.McConnell said it was appropriate for county engineers to address that portion of roadway, “because we have a high accident frequency in that whole stretch.”
“We had like 300 in the Navesink River probably four or five years ago during winter,” Skinner said.The Atlantic Flyway, the coastal migration route of North America, had an estimated 9,000 birds five years ago, according to the Atlantic Flyway Mute Swan Management Plan, an American-Canadian report released in July 2015.The Management Plan calls for such things as educating the public on mute swans, reducing the population to less than 2,000 by 2025, maintaining mute swans at an ecologically manageable level, preventing the expansion of their range and getting stakeholders involved in the process.“There is a large movement around the country to curb the population growth,” Skinner said. “Like any argument, there’s two sides.”A few years ago, New York State proposed gathering its population of mute swans and killing them – but it got push-back and it never came to fruition. Now, non-lethal methods are planned to reduce the population, such as preventing eggs from hatching.“With regard to eradication, this is very polarizing,” Temple said. “There is no easy answer. On one hand you want to restore the balance of the pond, but on the other hand, there is the humane treatment of a living creature.“Mute swans have a long lifespan and a tremendous reproductive capacity,” says Temple. “What do you do with the swans? Relocating them will only compound the problem by introducing them into areas where they didn’t exist before. Killing eggs has been shown to be ineffective in reducing the population because of the birds’ reproductive capacity.”“I don’t like to see a slaughter,” Bacinski said. “Most states will shoot them when they show up if they have not been established there.”Bacinski’s feelings on mute swans?“They’re dreadful,” Bacinski said. “When I see them, I sort of ignore them.” Naturalists Warn That Mute Swans Are Elegant DisruptersBy Joseph SapiaEARLIER THIS MONTH on the Shrewsbury River at Monmouth Beach, two large white swans, along with their two cygnets, casually approached two boats.“Somebody must be feeding them,” said someone on the boat.In the outdoors world, that may be one of the tamer comments made about “mute swans” – the swans seen this time of year, and year-round, on fresh or brackish local water ways and bodies of water.A serious birdwatcher may call them “harbor hogs” or “pond pigs,” reflecting the “dislike” birders have for them, said Pete Bacinski, an Atlantic Highlands resident who is a member of the state Waterfowl Advisory Committee and the retired director of New Jersey Audubon’s Sandy Hook Bird Observatory.Hoggish and piggish, not because they might want to mooch some food from friendly humans – a lot of animals do that. But because they are a non-native, invasive species that disrupts the natural world around them.Sam Skinner, a Monmouth County Park System naturalist, allows that mute swans are “beautiful birds,” but…“They pretty much take over, they’re the boss of the pond,” said Skinner, who is based at Huber Woods Park in Middletown. “They deplete the vegetation. They discourage other waterfowl – (and) not just water fowl.“And they attack humans,” Skinner said. “Give you a mean little bite, whack you with their wings.”“They are nasty to people,” Bacinski said. “They could literally take a finger off. Their beauty is the only good.”“Mute swans are a very polarizing issue,” said Dena Temple, public relations chair for the Monmouth County Audubon Society. “People think they are beautiful – and they are. However, they are a non-native species. And just as non-native plants disrupt the balance of the environment, so do non-native birds and other animals.”“All of the mute swans in North America descended from swans imported from Europe from the mid-1800s through the early 1900s to adorn large estates, city parks and zoos,” according to the Cornell University Lab of Ornithology website, allaboutbirds.org. “Escapees established breeding populations and are now established in the Northeast, Mid-Atlantic, Great Lakes, and Pacific Northwest.”And All About Birds notes the negative, “Their aggressive behavior and voracious appetites often disturb local ecosystems, displace native species and even pose a hazard to humans.”New Jersey has two native swans – tundras and trumpeters, which are winter species in New Jersey. In the Two River area, they are basically migrants, Bacinski said.“In the case of the mute swans, when a mute swan moves into an area pond, it’s a case of ‘there goes the neighborhood,’” Temple said.“Being a very large bird, they eat a lot and can decimate the aquatic vegetation in a pond, leaving little food for other birds,” said Temple. “They also disengage more plant material than they actu- ally consume, leaving the aquatic habitat destroyed for fish and invertebrates that breed in the cover of the aquatic vegetation.”Mute swans, Cygnus olor, are huge – about 4 feet to 5 feet in length with a wingspan of approximately 7 feet to 8 feet, weighing around 12 to almost 32 pounds, according to the Cornell University Lab of Ornithology’s website, allaboutbirds.org.They live long, perhaps 19 or 20 years and their cygnets – mostly two, sometime three – have a “75 to 80 percent survival rate because their parents are so protective,” Skinner said. So, when they are around, they are around to stay.
ARCADIA, Calif. (Feb. 12, 2017)–There was just one winning ticket in Sunday’s Pick Six at Santa Anita and it was worth $148,205.80. The “singleton” was purchased for $256.00 in Laughlin, NV.Sunday’s total Pick Six pool, comprised of $176,099 in “new money” and $33,967 from the track’s Single Ticket Pick Six Jackpot, totaled $210,066.There were 137 tickets with five winners, each worth $147.20.Santa Anita will embark upon a five day week on Thursday, with first post time at 1 p.m. Admission gates open at 12:30 p.m. For scratches, changes and complete morning line information, please visit santaanita.com.
West Indies cricket, the envy of the world for decades past because of its exiting and brilliant batsmen, fast and furious fast bowlers, and its acrobatic fielders, and undisputed champions of the world for 19 years up to 1995, is now at rock bottom and looks like getting deeper and deeper. In fact, based on the events of this week, and after all that have gone on in the past 15 or 20 years, a good bet is that the West Indies days are numbered. West Indies cricket is not the West Indies team alone. It is the West Indies teams and West Indies cricketers, all West Indian cricketers. And every penny belongs to the West Indies – to be added up, divided up fairly and equitably, and to be distributed to the players according to merit and on value to the team. The West Indies players have been on so many strikes, it has not been funny. Some have gone ahead, and some have been short-lived. Almost after every one of them there have been court cases, all sorts of meetings, all sorts of plans, and all sorts of MOUs and understandings. There have also been all kinds of pay structures agreed on. After 2014 and the Indian embarrassment, there were all kind of calls for all kinds of meetings, for all kinds of take-overs, and there were meetings involving prime ministers, Dave Cameron and board members, players, lawyers, and players association members. Although it is common knowledge that the West Indies have lost 80 of 132 Test matches while winning only 14 against the top eight teams since losing 5-0 to England in 2000 and 5-0 to Australia in 2000-1, and have failed to qualify for the Champions Trophy while Bangladesh have done so, cricket, results on the field, have nothing to do with it, not really. The problem which threatens to explode and blow West Indies to the four corners of the earth is money, pure and simply money. The West Indies are set to participate in the World Twenty20 tournament in March in India, but once again, as happened so many times in the recent past, including the 2014 Test tour of India, the squad of players, led by captain Daren Sammy, wrote the board, demanding more money for the services. In a nutshell, that’s what the players want, more money. The players, led by Sammy, want double the match fee, 50 per cent of sponsorship money, and 100 per cent of any prize-money won. On top of that, they don’t want to deal with the West Indies Players’ Association whatsoever. The board seems adamant that it will not pay. According to the board, it cannot pay. It is as simple as that. The board, if needs be, will select a new team for the tournament. The players claim they are losing money, that they are losing as much as 85 per cent of their money, and that they cannot afford that, even if some of that money is going to subsidise the salaries of contracted Caribbean first-class players for the newly formed Professional Cricket League. The West Indies players, it seems, cannot afford to subsidise Caribbean first-class players, not even for the suffering first-class players to go from getting nothing to getting something. The West Indies players, however, would be comfortable if they were to be, as they are now, subsidised by the cricket world from the money earned by the money-spinners elsewhere in the world. Is it right for the non-West Indies player to run around in the sun day after day for days at a time and then sit down and twiddle his thumbs, with nothing to do or eat, just looking on from the outside? No, it is not right, it was never right, and it can never be right. The West Indies Cricket Board has made many mistakes in their time, but this is not one. This is one to produce for West Indies cricket. This is one to ensure that what is happening now never happens again. This is one for West Indies cricket. Finding a vision Top eight teams There were mediations and arbitrations at which there were ICC representatives, FICA representatives, WICB members, WIPA members, and accountants, at which the players and the board discussed their responsibilities along with finding a vision of West Indies cricket. The meetings, all of them, one or the other, agreed and decided on all categories of remuneration, on player compensation re West Indies, international, franchise, or first-class levels, incentive payments, down to injury payments, and with the help and agreement of ICC and FICA.at that, according to the board. All this was done from May, and then suddenly, two few weeks before the deadline, comes another storm. “I am sending this as captain of the West Indies T20 side as a collective representative of the 15-man squad selected for the upcoming T20 World Cup,” said Sammy. And then he proceeded to say that WIPA does not represent the players, that the money is not what the players had expected, that they wanted it doubled at least, and he made it clear, in his first letter, that the players would not accept the current offer. “If you don’t agree to the above, would you consider that this matter goes to mediation for a settlement?” said Sammy. Michael Muirhead, CEO of the board, replied, politely, “If we should not hear from any player by February 14, we will presume that you have refused selection.” The West Indies payment structure was changed in 2014, partly by the ICC because of the money they decided to share around: 25 per cent of ICC cricket money guaranteed from the player pool per year, 53 per cent to international players, 47 per cent to 90 contracted first-class players, at the end of four years fund assessed and any excess will be paid to international players only. For all fees retainers, Test match fees, ODI fees, T20 fees, ICC, events, practice matches, captains fees, and per diems fees will be paid separately, worked out with WICB, WIPA, FICA, and ICC, who added on US$1,000 per day of cricket for each player who is not on a senior contract for the use of their image rights. According to the board, the retainer fees were increased in 2013 from US$5,000 to US$160,000 to most of the top players in the T20 league. Additionally, the windows are left open for Indian Premier League and Big Bash League twice a year. It is now possible for top West Indies players to earn, according the board, US$315,000 per year ($155,000 from WICB and $160,000 from CPL). West Indies cricket has so much money and no more, and they can pay only what they can afford to pay. The cricket has to be supported, and other players have to be looked after. Why, for example, wait from May until now to deal with these things? Money is money, and it is important, no doubt about it. There are times, however, when some things are more important, when one can do with a little less for the benefit of a brother or a sister. If this tour beaks up again, it may be the end of West Indies cricket. Trinidad and Tobago have already whispered the idea to members of the ICC, and Richard Pybus, West Indies director of cricket, has already said, just recently, “A split can’t be discounted in 10 years.” According to merit
Smith grabbed a bat for the first time out of necessity for the first time in his … CLICK HERE if you are having a problem viewing the photos on a mobile deviceSAN FRANCISCO — With the game on the line, there’s no one the Giants would rather have on the mound than closer Will Smith.At the plate? They’ll take Smith, too.“In the second or third inning, we were talking in the dugout about how he needs to get an at-bat.” second baseman Scooter Gennett said. “He was like, ‘I rake.’”
Scientists have created enzymes with enhanced ability to select between left- and right-handed molecules, using an “evolutionary” process, claims Manfred Reetz in a Perspective article in PNAS:1A fundamentally new approach to asymmetric catalysis in organic chemistry is described based on the in vitro evolution of enantioselective enzymes. It comprises the appropriate combination of gene mutagenesis and expression coupled with an efficient high-throughput screening system for evaluating enantioselectivity (enantiomeric excess assay). Several such cycles lead to a “Darwinistic” process, which is independent of any knowledge concerning the structure or the mechanism of the enzyme being evolved. The challenge is to choose the optimal mutagenesis methods to navigate efficiently in protein sequence space. As a first example, the combination of error-prone mutagenesis, saturation mutagenesis, and DNA-shuffling led to a dramatic enhancement of enantioselectivity of a lipase acting as a catalyst in the kinetic resolution of a chiral ester. Mutations at positions remote from the catalytically active center were identified, a surprising finding, which was explained on the basis of a novel relay mechanism. The scope and limitations of the method are discussed, including the prospect of directed evolution of stereoselective hybrid catalysts composed of robust protein hosts in which transition metal centers have been implanted.Basically, researchers built enzymes top-down instead of bottom-up. Instead of the old “rational design” method, trying to construct an active site to perform the function needed, they started with the function they wanted, and iteratively selected any “mutants” that came closest to doing the job, without stipulating how they did it. The “surprising finding” he spoke of was that a distant mutation, far from the active site, actually improved the performance of the enzyme.1Manfred T. Reetz, “Controlling the enantioselectivity of enzymes by directed evolution: Practical and theoretical ramifications,” Proceedings of the National Academy of Sciences USA, 10.1073/pnas.0306866101, published online before print April 12, 2004.He put “Darwinistic” in quotes, because it was not really Darwinistic, it was Designistic. The scientists played the role of designer by carefully selecting the results and directing the outcome. This paper, like others before it, gives two false impressions: (1) that Darwinism achieved the high specificity of proteins in the past, and (2) that Darwinian theory is a boon to science in the present. This is nothing but name-dropping. Charlie had nothing to do with it. If this were Darwinism, there would be no “directed evolution” (an oxymoron), because there would be no direction. Here, the scientists had a goal: they wanted enantioselective enzymes. Their “mutation and selection” process was results-driven by artificial selection, a form of intelligent design. Yet Reetz illogically claims, without any evidence or support (only belief), “Enzymes are products of evolution, and might therefore be expected to function with high enantioselectivity only with natural substrates under physiological conditions.” Then, in the very next breath, he falsifies this evolutionary prediction: “However, it is well known that this is not the case, because a surprisingly large number of unnatural compounds are converted with high enantioselectivity, even in organic solvents.” So does this convert him to ID theory? No, he just waltzes into the problem at hand: “Nevertheless, the problem of substrate specificity persists. In such cases several approaches to enhance enzyme stereoselectivity have been described, including site-specific mutagenesis based on theoretical considerations…” la te da, blah blah, and so on, and so forth, so we’ll design an enzyme with a creative method and give Charlie the glory. The difference between this method and the traditional bottom-up approach Reetz calls “rational design” can be compared to the difference between engineering and management. The engineer knows the physical laws and properties of the widget he is designing, and organizes the parts specifically toward the solution. The manager just says, “Build me a widget that flies.” An upper manager might devise a contest between engineers to see who can come up with the best design. All the manager cares about is the results: will it fly? He weeds out the losers and rewards the winners. The winner gets more resources to refine the design until an optimal design is produced. Even if the engineer uses trial and error and chance, given enough trials a working prototype will emerge as long as intelligence is directing the process toward a goal. In a similar way, these researchers did not need to know all the details of the structure of the enzyme they wanted to create; they just mutated ingredients and selected the few that worked, then iterated the process until the best design was filtered out of the pile. They managed the process rather than engineering it. Only Dilbert would nominate his manager for a Darwin award. Another thing. The “surprising” discovery Reetz made also argues against Darwinism. His team found that a remote amino acid, far from the active site, was essential to the function. He was so surprised by this he called it a paradigm-shifting finding: “This observation leads to a change in paradigm, because all previous attempts to influence enantioselectivity of an enzyme by using site-specific mutagenesis had focused on amino acid substitutions near the active center. Such protein engineering was designed to “carve” an appropriate chiral pocket at the active center, in line with Fischer’s “lock-and-key” hypothesis or modified versions such as Koshland’s induced fit. Later, he adds, “… our studies show that the long-standing dogma regarding the necessity of amino acid substitutions exclusively at the active site to influence enantioselectivity no longer holds.” What this means is that an enzyme is designed all the way through, not just at the active site. The “lock and key” fit of an enzyme to its substrate is amazing enough, but to think that distant amino acids actually affect the workings of the molecular machine calls into question the belief that proteins can be mutated at will, as long as they are far from the active site. This underscores the improbability of getting all the amino acids in the right order, as described in our online book, Evolution: Possible or Impossible? Let’s give credit where credit is due. This experiment is all about design. Calling this “Darwinistic” is like calling Boeing a manufacturer of tornados in junkyards.(Visited 44 times, 1 visits today)FacebookTwitterPinterestSave分享0
To build South Africans’ pride in the country’s natural, cultural and historical heritage, South African National Parks (SANParks) is offering free entry to citizens during SANParks Week. It runs from 12 to 16 September.“When people take pride in the national parks, they will start to understand the importance of conservation,” said SANParks acting head of communications, William Mabasa.#FreeAccess to National Parks starts in 2 weeks. Which Park will you be visiting? https://t.co/LrfOWBBpBL pic.twitter.com/xnfKFLkVGn— SANParks (@SANParks) August 30, 2016Started in 2006, the theme of the week this year is “Know your national parks”. Access to the parks is free to South Africans with a valid identity document; however, entry will also be free to children under the age of 16 without proof of identity.“It should be noted that the free access to the parks will not include accommodation and any commercial activities in the park such as guided safaris in vehicles or guided walks, etc,” said SANParks.Mabasa said this year’s SANParks Week would include exhibitions showcasing the myriad geographical regions of the parks. “The expo will include cultural, conservation, nursery and tourism aspects from the community, rangers and various conservation entities in order to highlight the broader South African biodiversity landscape.”Click here for a detailed list of the parks taking part in the initiative.Source: SANParks and South Africa.info reporterWould you like to use this article in your publication or on your website? See Using SouthAfrica.info material